A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm

It’s important to note that these studies used kudzu extract, which may have contained other parts of the kudzu plant besides the root. Thus, scientists need to do more research in this area on the effects of kudzu root specifically. Another study found that people who took puerarin, an isoflavone extract from the kudzu plant, prior to drinking took longer to consume alcoholic beverages (3). For over 2,000 years, people have used kudzu root in traditional Chinese medicine for purposes like treating fevers, diarrhea, and even diabetes and heart disease (1). The ability of puerarin and related isoflavones to facilitate alcohol’s entry into the brain has not been systematically studied. For this mechanism to be plausible, the more rapid penetration of alcohol into the brain would have to trigger a satiety mechanism rather quickly such that the desire for the next drink is delayed—thus interrupting a binge episode.

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  • This interpretation of kudzu’s possible mechanism of action was also suggested by Wong et al. (2011) who postulated that kudzu alters peripheral and cerebral blood flow.
  • If you have any questions about using kudzu recovery for alcoholism, please leave them in the comment box below.
  • Something has to create a massive increase in sense of well-being to fit into this category.
  • The present study provides further evidence that extracts of the kudzu root are effective in reducing alcohol consumption but unlike any other medication (other than disulfiram) it does so after a single dose was taken shortly before a binge drinking opportunity.
  • The safety of kudzu extract was monitored via a number of methods including twice weekly assessments of vital signs (resting pulse, blood pressure), collecting daily reports of side effects using a daily diary and twice weekly assessments of adverse events by study staff.
  • While kudzu root may offer a few specific benefits, there are also some potential downsides to consider.

Amount of beer consumed during drinking session after either placebo or puerarin treatment for 7 d. Anti-inflammatory properties are attributed to decreased prostaglandin E2 and tumor necrosis factor-alpha release, both of which are involved in inflammatory processes (3). The isoflavone tectorigenin demonstrated antiproliferative activity via cell differentiation and reduced expression of Bcl-2, an antiapoptotic protein (1). In animal studies, peurarin may alleviate chronic alcoholic liver injury via inhibition of endotoxin gut-leakage, activation of Kupffer cells, and expression of lipopolysaccharide receptors (22). On average, the participants drank 1 1/2 beers while on kudzu treatment during the 1 1/2-hour sessions, compared with 2 1/2 beers during the placebo treatment.

1. Animal Study

Kudzu root is an edible part of a climbing vine that’s native to many Asian countries. It’s been used for health purposes in Traditional Chinese kudzu to stop drinking Medicine for a really long time. For instance, it may reduce the effectiveness of birth control due to its estrogenic effects (8, 17).

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Kudzu vine extract for alcohol treatment

This change in drinking topography was not secondary to alterations in the subjective effects of alcohol as kudzu-treated individuals still reported positive feelings (e.g., drunk, floating) without any change in the negative effects (e.g., clumsy, dizzy). The apparently lower magnitude of subjective effects compared to the placebo treated group (Figure 4) is due most likely to the fact that the kudzu-treated individuals drank less alcohol during the session, which was reflected in significantly lower breath alcohol levels. When given equal amounts of alcohol, kudzu- and placebo-treated individuals respond similarly (Penetar et al., 2011). The rates of alcohol drinking during follow-up phase were also reduced compared to baseline in both the kudzu- and placebo-treated groups. We had not expected that any beneficial effects would remain after kudzu extract had cleared the body based on our pharmacokinetic results (Penetar et al., 2006). Extracts of the kudzu plant are best known for their ability to suppress alcohol intake or alter alcohol effects by laboratory animals (Heyman et al., 1996; Keung and Vallee, 1993b; Keung, 2003; Overstreet et al., 1996; Rezvani et al., 2003; Benlhabib et al., 2004).

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Fancy a drink? The whole truth about Ireland’s relationship alcohol from Dr Michael Mosley.

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However, the researchers did note that treatment with kudzu caused an increase in heart rate, skin temperature and blood ethanol levels in the participants. Based on this, the researchers hypothesized that an increase in blood ethanol levels could translate into increased effects from the first alcoholic drink and delay an individual’s desire for subsequent drinks. One such natural medicine that has been found to be effective in reducing alcohol intake is Kudzu.

Kudzu vine extract for alcohol treatment

In an alcohol withdrawal-induced hyperexcitability paradigm of mice, acute and chronic administration of berberine (10 and 20 mg/kg) dose-dependently attenuated alcohol withdrawal-induced hyperexcitability signs, the effects were identical to diazepam (1.25 and 2.5 mg/kg). Moreover, berberine had a positive effect on gastrointestinal injury induced by overconsumption of alcohol in vivo and in vitro. The results showed https://ecosoberhouse.com/ that berberine inhibited increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as upstream signals TLR2 and TLR4, and regulated cytokines [129]. Therefore, Rhizoma coptidis might reduce alcohol intake through its neuromodulatory action. All of the above mentioned mechanisms, with the exception of a disulfiram-like one, require repeated administration and time to develop.

  • They can give you personalized advice that takes into account any other supplements or medications you may be taking.
  • Participants were instructed to always keep the beer glass on the table except when taking a sip.
  • Three drugs approved by United State Food and Drug Administration are available for the treatment of alcohol use disorder, that is, disulfiram, naltrexone and acamprosate.

4 Alcohol Consumption—Baseline Phase

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